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  • Publications
    • A Unique Type V CRISPR-Cas System Encoded by a Group of Thermus Viruses
    • An updated evolutionary classification of CRISPR--Cas systems including rare variants
    • Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
    • Diversity, evolution, and classification of the RNA-guided nucleases TnpB and Cas12
    • Widespread CRISPR-derived RNA regulatory elements in CRISPR-Cas systems
    • Erratum for Benler et al.,“Cargo Genes of Tn 7-Like Transposons Comprise an Enormous Diversity of Defense Systems, Mobile Genetic Elements, and Antibiotic Resistance Genes”
    • Analysis of metagenome-assembled viral genomes from the human gut reveals diverse putative CrAss-like phages with unique genomic features
    • Cargo genes of Tn 7-like transposons comprise an enormous diversity of defense systems, mobile genetic elements, and antibiotic resistance genes
    • CRISPRidentify: identification of CRISPR arrays using machine learning approach
    • Evolution of type IV CRISPR-Cas systems: insights from CRISPR loci in integrative conjugative elements of Acidithiobacillia
    • Thousands of previously unknown phages discovered in whole-community human gut metagenomes
    • Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems
    • CRISPR arrays away from cas genes
    • DNA targeting by Clostridium cellulolyticum CRISPR--Cas9 Type II-C system
    • Evolutionary classification of CRISPR--Cas systems: a burst of class 2 and derived variants
    • Machine-learning approach expands the repertoire of anti-CRISPR protein families
    • Mapping CRISPR spaceromes reveals vast host-specific viromes of prokaryotes
    • PpCas9 from Pasteurella pneumotropica—a compact Type II-C Cas9 ortholog active in human cells
    • Unique genomic features of crAss-like phages, the dominant component of the human gut virome
    • Unprecedented diversity of unique CRISPR-Cas-related systems and Cas1 homologs in Asgard archaea
    • Vast diversity of anti-CRISPR proteins predicted with a machine-learning approach
    • Comparative genomics and evolution of trans-activating RNAs in Class 2 CRISPR-Cas systems
    • CRISPR--Cas in mobile genetic elements: counter-defence and beyond
    • Systematic prediction of functionally linked genes in bacterial and archaeal genomes
    • Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis
    • Towards comprehensive characterization of CRISPR-linked genes
    • Cas13b is a type VI-B CRISPR-associated RNA-guided RNase differentially regulated by accessory proteins Csx27 and Csx28
    • Diversity and evolution of class 2 CRISPR--Cas systems
    • Dynamics of Escherichia coli type I-E CRISPR spacers over 42 000 years
    • On the origin of reverse transcriptase-using CRISPR-Cas systems and their hyperdiverse, enigmatic spacer repertoires
    • Phylogenomics of Cas4 family nucleases
    • Recruitment of CRISPR-Cas systems by Tn7-like transposons
    • The CRISPR spacer space is dominated by sequences from species-specific mobilomes
    • A pipeline approach for discovery of novel CRISRP-Cas systems
    • Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation
    • C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
    • Metagenomic analysis of bacterial communities of Antarctic surface snow
    • Recent mobility of casposons, self-synthesizing transposons at the origin of the CRISPR-Cas immunity
    • Discovery and functional characterization of diverse class 2 CRISPR-Cas systems
    • MD 20894, USA 3 Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA, McGovern Institute for Brain Research, Department of Brain and Cognitive Science, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts
    • Pervasive generation of oppositely oriented spacers during CRISPR adaptation

CRISPR arrays away from cas genes

Jan 1, 2020·
Sergey A Shmakov
,
Irina Utkina
,
Yuri I Wolf
,
Kira S Makarova
,
Konstantin V Severinov
,
Eugene V Koonin
· 1 min read
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Last updated on Jan 1, 2020

← Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems Jan 1, 2021
DNA targeting by Clostridium cellulolyticum CRISPR--Cas9 Type II-C system Jan 1, 2020 →

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